The central theme of research at the Department of Neuroscience is “Plasticity and Dynamics of Sensori-Motor Systems”. This central theme is investigated using a variety of technical approaches, including molecular biology, cell biology and physiology, neuroanatomy, systems electrophysiology, and behavioral and clinical studies. At the systems level the research topics of the individual groups focus on transduction mechanisms or motor learning. Of special interest are the interactions of visual, auditory, vestibular or proprioceptive sensory inputs with motor outputs such as the oculomotor system, locomotion, and hand and neck movements. At the cellular level the research topics center around the synaptic mechanisms underlying these dynamic and plastic processes. Below you can find the research topics of the individual groups.

Principal investigator Research topic
Gerard BorstSynaptic transmission in the auditory brainstem and midbrain
Marcel de JeuNeuronal processing of the olivocerebellar system
Chris de ZeeuwRegulation of sensorimotor integration in mouse mutants
Martijn SchonewilleRegulation of sensorimotor integration in mouse mutants
Ype ElgersmaMolecular and cellular mechanisms underlying learning and neurodevelopmental disorders
Maarten FrensCerebellar systems physiology
Freek HoebeekThalamic studies on cerebello-cerebral interactions
Joan HolstegeAnatomical and functional organization of the spinal cord
Dick JaarsmaThe pathogenesis of amyotrophic lateral sclerosis (ALS)
Gert-Jan KleinrensinkDisturbances in neural control of movement
Bas KoekkoekAssociative learning
Steven KushnerIntegrative neurobiology of psychiatric disorders
Tom RuigrokFunctional neuroanatomy of the cerebellum
Jos van der GeestHuman neurophysiology
Marcel van der HeijdenThe auditory periphery
Johan PelVisual-motor and visual vestibular interactions