The central theme of research at the Department of Neuroscience is “Plasticity and Dynamics of Sensori-Motor Systems”. This central theme is investigated using a variety of technical approaches, including molecular biology, cell biology and physiology, neuroanatomy, systems electrophysiology, and behavioral and clinical studies. At the systems level the research topics of the individual groups focus on transduction mechanisms or motor learning. Of special interest are the interactions of visual, auditory, vestibular or proprioceptive sensory inputs with motor outputs such as the oculomotor system, locomotion, and hand and neck movements. At the cellular level the research topics center around the synaptic mechanisms underlying these dynamic and plastic processes. Below you can find the research topics of the individual groups.
Research
| Principal investigator | Research topic |
|---|---|
| Durk Fekkes | |
| Chris de Zeeuw | Regulation of sensorimotor integration in mouse mutants |
| Gerard Borst | Synaptic transmission in the auditory brainstem and midbrain |
| Maarten Frens | Cerebellar systems physiology |
| Ype Elgersma | Molecular and cellular mechanisms underlying learning and mental retardation disorders |
| Casper Hoogenraad | Protein trafficking and synapse function |
| Hans van der Steen | Plasticity in 3D visuo-vestibular interactions |
| Joan Holstege | Anatomical and functional organization of the spinal cord |
| Jos van der Geest | Human neurophysiology |
| Bas Koekkoek | Associative learning |
| Marcel de Jeu | Neuronal processing of the olivocerebellar system |
| Dick Jaarsma | The pathogenesis of amyotrophic lateral sclerosis (ALS) |
| Gert-Jan Kleinrensink | Disturbances in neural control of movement |
| Tom Ruigrok | Functional neuroanatomy of the cerebellum |
| Marcel van der Heijden | The auditory periphery |
| Arthur Houweling | Neural coding in the barrel somatosensory cortex |